G protein‐coupled receptors (GPCRs) constitute the largest family of transmembrane proteins and play a crucial role in regulating diverse cellular functions. They transmit their signaling via binding to intracellular signal transducers and effectors, such as G proteins, GPCR kinases, and β‐arrestins. To influence specific GPCR signaling behaviors, β‐arrestins recruit effectors to form larger signaling complexes. Intriguingly, they facilitate divergent functions for the binding to different receptors. Recent studies relying on advanced structural approaches, novel biosensors and interactome analyses bring us closer (...) to understanding how this specificity is achieved. In this article, we share our hypothesis of how active GPCRs induce specific conformational rearrangements within β‐arrestins to reveal distinct binding interfaces, enabling the recruitment of a subset of effectors to foster specialized signaling complexes. Furthermore, we discuss methods of how to comprehensively assess β‐arrestin conformational states and present the current state of research regarding the functionality of these multifaceted scaffolding proteins. (shrink)

D. D. Raphael examines the moral philosophy of Adam Smith (1723-90), best known for his famous work on economics, The Wealth of Nations, and shows that his thought still has much to offer philosophers today. Raphael gives particular attention to Smith's original theory of conscience, with its emphasis on the role of 'sympathy' (shared feelings).

Les écrits de Kant sur les races humaines, émaillés de caractérisations et de jugements qui heurtent notre sensibilité contemporaine, sont accueillis par un silence gêné des commentateurs. Ceux-ci croient bon de s'abstenir d'analyser ces textes, et d'y voir a priori des opinions mal élaborées, victimes de l'air du temps. Mais en évitant de se confronter à ce tabou, ils jouent aussi un mauvais tour à Kant. Car le lecteur peut avoir l'impression qu'on lui cache quelque chose. Qui plus est, les (...) textes sur les races font preuve d'une cohérence interne et d'une compacité théorique remarquables, et leur puissance explicative est inégalée dans le champ de l'anthropologie physique de son époque - celle de Buffon, de Blumenbach ou de Meiners. Est-ce à dire, comme le craignent d'avance les commentateurs, qu'on trouve chez Kant un authentique racisme théorique? En fait, cette accusation de racisme n'a pas vraiment d'objet à une époque où les modalités d'une pensée non raciste, c'est-à-dire d'une anthropologie non naturaliste, étaient au mieux en cours de constitution. Ce constat nous mène à considérer que seule une analyse dépassionnée des thèses raciologiques de Kant, prises dans toute leur violence, peut rendre justice à la doctrine kantienne. Nous ne cherchons pas à produire une " disculpation théorique " de Kant. Mais inversement, cet ouvrage ne vise pas non plus à formuler des thèses scandaleuses ou à révéler un " Kant non universaliste ". Il entend simplement montrer la tension d'une pensée qui fait de l'histoire un processus de civilisation en principe universel, articulé autour d'un centre de gravité à la fois géographique et spirituel, l'Europe, peuplée d'hommes blancs. Cet ouvrage intéressera les étudiants et chercheurs en philosophie et en histoire des sciences, mais aussi les étudiants et chercheurs en anthropologie. (shrink)

Deliberative democracy grounds its legitimacy largely in the ability of speakers to participate on equal terms. Yet theorists and practitioners have struggled with how to establish deliberative equality in the face of stark differences of power in liberal democracies. Designers of innovative civic forums for deliberation often aim to neutralize inequities among participants through proportional inclusion of disempowered speakers and discourses. In contrast, others argue that democratic equality is best achieved when disempowered groups deliberate in their own enclaves before entering (...) the broader public sphere. Borrowing from each perspective, the authors argue that there are strong reasons to incorporate enclave deliberation among the disempowered within civic forums. They support this claim by presenting case study evidence showing that participants in such forums can gain some of the same benefits of deliberation found in more heterogeneous groups, can consider a diversity of viewpoints rather than falling into groupthink and polarization, and can persuade external stakeholders of the legitimacy of the group’s deliberations. (shrink)

The tale of Gyges' ring narrated by Cicero atDe officiis3.38 is of course originally found, and acknowledged as such by Cicero, in Plato (Resp.359c–360b). I would like in this paper to address two questions about Cicero's handling of the tale – one historical, one philosophical. The purpose of the historical question is to evaluate, with respect to the Gyges narration, Cicero's quality as a reader of Plato. How well does Cicero understand the role of the story in its original Platonic (...) context? The motivation for the question is that, at first blush, Cicero seems to have badly misunderstood it. I shall argue that the appearance is illusory, and that Cicero understands the tale's Platonic provenance perfectly well. Now it should be noted that the question of Cicero's grasp of the tale's purpose in Plato is distinct from the question whether Cicero himself puts the story to the same or a different use than Plato did. I shall suggest that while there are striking points of contact between the two treatments, on one crucial feature – namely the tale's ostentatiously far-fetched nature – Cicero is instructively more explicit than Plato. (shrink)

Philosophy is one of the most intimidating and difficult of disciplines, as any of its students can attest. This book is an important entry in a distinctive new series from Routledge: The Great Philosophers . Breaking down obstacles to understanding the ideas of history's greatest thinkers, these brief, accessible, and affordable volumes offer essential introductions to the great philosophers of the Western tradition from Plato to Wittgenstein. In just 64 pages, each author, a specialist on his subject, places the philosopher (...) and his ideas into historical perspective. Each volume explains, in simple terms, the basic concepts, enriching the narrative through the effective use of biographical detail. And instead of attempting to explain the philosopher's entire intellectual history, which can be daunting, this series takes one central theme in each philosopher's work, using it to unfold the philosopher's thoughts. (shrink)

The Controversy over the Existence of the World (henceforth Controversy) is the magnum opus of Polish philosopher Roman Ingarden. Despite the renewed interest for Ingarden’s pioneering ontological work whithin analytic philosophy, little attention has been dedicated to Controversy's main goal, clearly indicated by the very title of the book: finding a solution to the centuries-old philosophical controversy about the ontological status of the external world. -/- There are at least three reasons for this relative indifference. First, even at the time (...) when the book was published, the Controversy was no longer seen as a serious polemical topic, whether it was disqualified as an archaic metaphysical pseudo-problem, or taken to be the last remnant of an antiscientific approach to philosophy culminating in idealism and relativism. Second, Ingarden’s reasoning on the matter is highly complex, at times misleading, and even occasionally faulty. Finally, his analysis is not only incomplete – Controversy being unachieved – but also arguably aporetic. -/- One may wonder, then, why it is still worth excavating this mammoth treatise to study an issue apparently no longer relevant to contemporary philosophy. Aside from historical and exegetical purposes, which are of course very interesting in their own right, Ingarden’s treatment of the Controversy remains one of the most detailed and ambitious ontological undertakings of the twentieth century. Not only does it lay out an incredibly detailed map of possible solutions to the Controversy, but it also tries to show why the latter is a genuine and fundamental problem that owes its hasty disqualification to various oversimplifications over the course of the history of philosophy. -/- In this chapter, I first give an overview of Ingarden’s method, which relies mainly on a combinatorial analysis. Then, I summarize his examination of possible solutions to the Controversy, and determine which ones can be ruled out on ontological grounds. Finally, I explain why this ambitious project ultimately leads to a theoretical impasse, leaving Ingarden unable to come up with a definitive solution to the Controversy – regardless of the fact that the book is unachieved. I argue that his analysis of the problem yields a more modest but nonetheless valuable result. (shrink)

NON-DUALISM, DUALISM AND MONISM Q.1 What do the following terms, often used by the Vedanta: dualism, monism, monotheism and non-dualism, mean? A. Every philosophical or cosmological vision which affirms two opposing and irreducible...

Cicero's philosophical works introduced Latin audiences to the ideas of the Stoics, Epicureans and other schools and figures of the post-Aristotelian period, thus influencing the transmission of those ideas through later history. While Cicero's value as documentary evidence for the Hellenistic schools is unquestioned, Cicero: The Philosophy of a Roman Sceptic explores his writings as works of philosophy that do more than simply synthesize the thought of others, but instead offer a unique viewpoint of their own. In this volume (...) class='Hi'>Raphael Woolf describes and evaluates Cicero's philosophical achievements, paying particular attention to his relation to those philosophers he draws upon in his works, his Romanizing of Greek philosophy, and his own sceptical and dialectical outlook. The volume aims, using the best tools of philosophical, philological and historical analysis, to do Cicero justice as a distinctive philosophical voice. Situating Cicero's work in its historical and political context, this volume provides a detailed analysis of the thought of one of the finest orators and writers of the Roman period. Written in an accessible and engaging style, Cicero: The Philosophy of a Roman Sceptic is a key resource for those interested in Cicero's role in shaping Classical philosophy. (shrink)

The claim that consciousness constitutively involves self-consciousness has a long philosophical history, and has received renewed support in recent years. My aim in this paper is to argue that this surprisingly enduring idea is misleading at best, and insufficiently supported at worst. I start by offering an elucidatory account of consciousness, and outlining a number of foundational claims that plausibly follow from it. I subsequently distinguish two notions of self-consciousness: consciousness of oneself and consciousness of one’s experience. While “self-consciousness” is (...) often taken to refer to the former notion, the most common variant of the constitutive claim, on which I focus here, targets the latter. This claim can be further interpreted in two ways: on a deflationary reading, it falls within the scope of foundational claims about consciousness, while on an inflationary reading, it points to determinate aspects of phenomenology that are not acknowledged by the foundational claims as being aspects of all conscious mental states. I argue that the deflationary reading of the constitutive claim is plausible, but should be formulated without using a term as polysemous and suggestive as “self-consciousness”; by contrast, the inflationary reading is not adequately supported, and ultimately rests on contentious intuitions about phenomenology. I conclude that we should abandon the idea that self-consciousness is constitutive of consciousness. (shrink)

Many see the mithnagdim as total rationalists. Therefore it has been assumed that R. Hayyim of Volozhin’s approach to Torah study was the same. Although rationalism may be a correct characterization of the method he used in talmudic study, it does not capture how R. Hayyim understood the essence of Torah study. Some have described Nefesh ha-Hayyim as demystifying Kabbalah. I agree that R. Hayyim opposes ecstatic Kabbalah. However, already in 1972 Norman Lamm noticed that R. Hayyim saw Torah study (...) as a form of clinging to God. In my article, I go further and demonstrate how torah lishmah for R. Hayyim is a radical idea that includes a legitimate path to unio mystica, and even a way to divine inspiration. (shrink)

Even though anthropogenic climate change is largely caused by industrialized nations, its burden is distributed unevenly with poor developing countries suffering the most. A common response to livelihood insecurities and destruction is migration. Using Peter Singer's ‘historical principle’, this paper argues that a morally just evaluation requires taking causality between climate change and migration under consideration. The historical principle is employed to emphasize shortcomings in commonly made philosophical arguments to oppose immigration. The article concludes that none of these arguments is (...) able to override the moral responsibility of industrialized countries to compensate for harms that their actions have caused. (shrink)

Maturity, that is often gained under the hammer of suffering, sooner or later will force us to remove the Eye of intelligence from things that are not (world of duality) and direct it toward the splendor of one's own essential nature. Undoubtedly, this implies an overturning of values, a psychological revolution, tending no longer toward the ineffective and unfruitful horizontal line, but toward the vertical one leading to awakening, to the unveiling of marvellos potentialities, the prerogative of the human soul.

The author offers an introduction to Plato's thought aimed at realizing Plato's teaching about being a real philosopherNone who sees the WholeNwhile leaving the task of meditating on Plato's texts to the reader.

There has been much written of late on the topic of panentheism. Dissatisfied with many contemporary descriptions of “panentheism” and the related “pantheism,” which we feel arise out of theistic presuppositions, we produce our own definition of sorts, rooted in and paying respect to the term’s etymology and the concept’s roots in Indian religion and western philosophy. Furthermore, we consider and comment on the arguments and comments concerning panentheism’s definition and plausibility put forth by Göcke, Mullins, and Nickel.

This monograph offers a critique of arguments for the existence of a specifically Christian God advanced by prominent scholar William Lane Craig. The discussion incorporates philosophical, mathematical, scientific, historical, and sociological approaches. The author does not seek to criticize religion in general, or Christianity specifically. Rather, he examines the modern and relatively sophisticated evidential case for Christian theism. Scholars have been arguing for theism or naturalism for centuries, and there seems little to add to the discussion, especially from the theistic (...) side. However, to assume that either theism or naturalism obtains is a false dichotomy. There are alternatives to both that merit consideration. Employing a probabilistic approach, the author advances this discussion. His work uniquely utilizes not only naturalistic hypotheses to argue against theism. It also presents supernaturalistic hypotheses. This leaves no question that theism is almost certainly false, even if some form of divine reality exists. This project seeks not to argue that Christianity or any other faith or religion is undesirable, but only to critically examine evidentialist claims posited by Christianity’s learned apologists. In fact, a major secondary aim is to consider alternative god-conceptions, such as polytheism and pantheism. This work aims to highlight that Christian theism is often granted special privileges by theistic philosophers of religion, which seems doubly inappropriate when certain alternative god-conceptions may even prove to be more plausible. (shrink)

Physicalism is the thesis that everything is physical. But what does it mean to say that everything is physical? Daniel Stoljar has recently argued that no account of the physical is available which allows for a formulation of physicalism that is both possibly true and deserving of the name. As against this claim, I argue that a version of the via negativa—roughly, the view that the physical is to be characterised in terms of the nonmental—provides just such an account.

To what extent is possession of truth considered a good thing in the Republic? Certain passages of the dialogue appear to regard truth as a universal good, but others are more circumspect about its value, recommending that truth be withheld on occasion and falsehood disseminated. I seek to resolve this tension by distinguishing two kinds of truths, which I label 'philosophical' and 'non-philosophical'. Philosophical truths, I argue, are considered unqualifiedly good to possess, whereas non-philosophical truths are regarded as worth possessing (...) only to the extent that possession conduces to good behaviour in those who possess them. In the non-philosophical arena it is an open question, to be determined on a case-by-case basis, whether falsehood is more efficacious in furthering this practical aim than truth. (shrink)

Bayne and Carter argue that the mode of consciousness induced by psychedelic drugs does not fit squarely within the traditional account of modes as levels of consciousness, and favor instead a multi-dimensional account according to which modes of consciousness differ along several dimensions—none of which warrants a linear ordering of modes. We discuss the assumption that psychedelic drugs induce a single or paradigmatic mode of consciousness, as well as conceptual issues related to Bayne and Carter’s main argument against the traditional (...) account. Finally, we raise a set of questions about the individuation of dimensions selected to differentiate modes of consciousness that could be addressed in future discussions of the multi-dimensional account. (shrink)

We present a self‐contained analysis of some reduction games, which characterise various natural subclasses of the first Baire class of functions ranging from and into 0‐dimensional Polish spaces. We prove that these games are determined, without using Martin's Borel determinacy, and give precise descriptions of the winning strategies for Player I. As an application of this analysis, we get a new proof of the Baire's lemma on pointwise convergence.

This article concerns the notion of living bodies that Spinoza develops in the Ethics (published posthumously in 1677). While commentators have emphasized the relevance of Spinoza’s works for contemporary physiology, they have neglected to study Spinoza’s own views on this topic. My aim is to draw attention to the specific parti pris that underlies Spinoza’s passages on anatomy. To do so, I first compare Spinoza’s claims on human body with the conceptions developed in his immediate historical environment. Then, I propose (...) to draw a parallel between Lakatos’s notion of “negative heuristics” and the high level of generalization Spinoza demonstrates in his propositions on the human body. This parallel allows me to show how Spinoza’s critical remarks on our knowledge of human body have heuristic value. (shrink)

A short book combining extracts from the work of one of the world's greatest thinkers with commentary from one of Britain's most distinguished writers on philosophy.

The main title of this work is a little misleading. Hobbs does not begin to consider in any detail Plato’s relation to traditional Greek models of the hero until chapter 6, nearly two-thirds of the way through the book. In fact, Hobbs’s treatment of Plato’s re-working of the hero-figure is embedded in a nexus of themes revolving round the Greek virtue of andreia and its psychological basis in that part of the soul that Plato in the Republic calls the thumos. (...) Commonly translated ‘spirit’, the term is notoriously hard to render by a single English equivalent. Plato’s conception of this human drive can be captured, according to Hobbs’s succinct phrase, as “the need to believe that one counts for something”. (shrink)

Cet article constitue la présentation des recherches effectuées par une équipe franco-grecque sur le tell de Kirrha en Phocide entre 2008 et 2015, et représente la publication préliminaire des structures archéologiques mises au jour. Deux secteurs distants l’un de l’autre ont été fouillés, révélant une dense occupation de l’Helladique Moyen, ainsi que des niveaux s’étageant jusqu’à l’Helladique Récent III. Notamment, une nécropole de la période transitionnelle (Helladique Moyen III – Helladique Récent I/II) a été fouillée dans la partie occidentale du (...) site, tandis que des niveaux mycéniens ont été reconnus à proximité du sommet. (shrink)

1. The theory of classes presented in this paper is a simplification of that presented by J. von Neumann in his paper Die Axiomatisierung der Mengenlehre. However, this paper is written so that it can be read independently of von Neumann's. The principal modifications of his system are the following.(1) The idea of ordered pair is defined in terms of the other primitive concepts of the system. (See Axiom 4.3 below.)(2) A much simpler proof of the well-ordering theorem, based on (...) von Neumann's equivalence axiom (Axiom 2.2 below) is given. (More exactly, the theory of ordinal numbers, on which the proof of the well-ordering theorem is based, is simplified—see §8.)(3) Functions are not assumed to be defined for all arguments. In place of “ = A” we have “is undefined.” This makes possible a constructive interpretation of the system. (See §2.)2. We wish first to give a rough picture of the system which we are trying to construct. Suppose that we have the idea “class,” but no material from which to construct classes. Nevertheless, we can construct the class 0 having no elements. And then the class 1 having 0 as its only element. And then the classes {1}, and {0, 1}, etc., using always the previously constructed classes as elements. To extend this method to infinite classes, we must give rules telling what elements are to be included. Since the nature of the rules which we can use is not altogether clear, we try to formalize the whole system; that is, to set up a system of axioms which seems to characterize this system of classes. Now in this set of axioms we find it necessary to use the idea of function (in the “Axiom of Replacement”). (shrink)

ABSTRACTThe aim of this article is twofold: first, to show that, in Plato'sHippias Major,Hippias is the mouthpiece of a materialist ontology; second, to discuss the critique of this ontology. My argument is based on an interpretation ofHippias Major300b4–301e3. I begin by revealing the shortcomings of P. Woodruff's and I. Ludlam's interpretations. Next, I define the concept of materialism as it was understood in ancient Greece in order to outline the specificity of Hippias' materialism. Finally, I argue that the opposition between (...) the two characters of theHippias Majorrepresents in fact an ontological opposition between two conceptions of what a unity is, i.e., Hippias' elementary corporal unities and Socrates' “formal unity.”. (shrink)

Olympism often presents itself as “a philosophy of life” aiming to promote “a peaceful society.” Pierre de Coubertin (1863-1937), the founder of the modern Olympics Games, is often seen as a great humanist in the history of modern sport. Indeed, scholars often state that Coubertin has worked all his life to promote social and international peace by the means of sports. In this respect, the “Olympic Truce” would stand as a symbol of the pacifists aims of Olympism. However, as my (...) paper aims to show, those common depictions of Olympism rest on a misunderstanding of Pierre de Coubertin's conceptions of peace, conflict, and sport. First, Coubertin does not understand peace as a condition which excludes human conflicts. Second, he defined sports as a means for social control. Third, in Coubertin, sports are not directly a means to promote pacifists ideals. Rather, peace appears as means to promote the values and ideas embodied by the sportsman. My study delves into this ambivalent relation between peace and sport in Coubertin. (shrink)

Aristotle’s research on happiness in the Eudemian Ethics has its proper start at EE I 7, as the first six chapters of the book are described as a preamble. This being so, a question arises about the kind of relation that obtains between the preamble and the main text. Is the preamble a mere introduction to the research, or is it possible that the arguments developed in the research of the EE depend on what has been presented in the preamble? (...) We believe that an analysis of the argument put forward in EE I 7 may shed some light on the question. We will sustain that this argument at least takes one of its premises from the preamble and so cannot proceed without relying on what has been presented in the introduction of the text. (shrink)

This article examines the utopianism of Kim Stanley Robinson's 2017 sf novel New York 2140, the world of which is defined by a nexus of profound climatological disasters. In contrast to other texts in the growing cli-fi genre, Robinson's seemingly apocalyptic world is a representation of a disaster utopia—real-world networks of care, compassion, collaboration, and utopian joy that emerge in the wake of disasters. In New York 2140 Robinson explores the valences of disaster utopianism beyond its contemporary, exceptional appearances, contemplating (...) how communities can flourish in a world where disaster emerges as a direct result of capitalist precarity and inequality. The article situates New York 2140 within a newly emerging corpus of cultural work that calls for a direct confrontation with the destructive powers of the present by understanding utopia as a precarious and never-finished form of resistance to neoliberal late capitalism. (shrink)

In his recent article in Sophia, Benedikt Paul Göcke concluded that ‘as long as we do not have a sound argument entailing the necessity of the world, panentheism is not an attractive alternative to classical theism’ : 75). As the article progresses, Göcke clarifies his view of what panentheism is, essentially identical to Göcke’s view of classical theism in every way, except in the world’s modal relation to God. This concept is vastly different to many of the panentheistic notions that (...) are more commonly held. While it is not initially made transparent—especially with the label Göcke chooses to use—it becomes increasingly clear that Göcke critiques a God concept of his own making. More common variations of panentheism are contrasted with Göcke’s version, in order to provide a broader and more accurate view of the ancient concept, and to demonstrate that Göcke’s view of panentheism is idiosyncratic. It is finally explained that even if Göcke’s view of panentheism were definitive, he has not successfully argued for the relative unattractiveness of the concept, relative to his view of classical theism. (shrink)

This paper sets out to re-examine the famous Wax Tablet model in Plato's Theaetetus, in particular the section of it which appeals to the quality of individual souls' wax as an explanation of why some are more liable to make mistakes than others (194c-195a). This section has often been regarded as an ornamental flourish or a humorous appendage to the model's main explanatory business. Yet in their own appropriations both Aristotle and Locke treat the notion of variable wax quality as (...) an important part of the model's utility in dealing with mistake. What, then, is its status for Plato? I shall argue that the section on variable wax quality is there to suggest to the reader a tempting way of misinterpreting the model. This will highlight the distinctive character of the model in its original version, and provide an unusual example of a philosopher describing how not to read one of his own doctrines. (shrink)

This article seeks to extend and refine Alastair MacIntyre’s moral theory of virtue ethics, by probing behind the Benedictine Rule—so fulsomely invoked at the end of After Virtue—to the ascetical theology of the noted, Eastern, ‘Cappadocian’ theologian of the fourth century: Gregory of Nyssa. I shall argue that Gregory’s vision of ascetical bodily practice complicates MacIntyre’s contemporary appropriation of virtue ethics. It does so by underscoring the diachronic, developmental character of personal ethical maturation—a theme which finds no expression in MacIntyre’s (...) otherwise sophisticated account of ‘narrative’. (shrink)

Father Raphael C. McCarthy Doctor of Philosophy of London University and Professor of Experimental Psychology at St. Louis University, contributes this paper as a general estimate of the influence which one man has exerted upon the vast and complex network of scientific world thought. We also acknowledge our indebtedness for this paper to Mr. William J. Miller of the School of Philosophy, who prepared it for those pages.

Central to Bataille’s critique of Hegel is his reading in ‘Hegel, Death, and Sacrifice’ of ‘negation’ and of ‘lordship and bondage’ in the Phenomenology of Spirit. Whereas Hegel invokes negation as inclusive of death, Bataille points out that negation in the dynamic of lordship and bondage must of necessity be representational rather than actual. Derrida, in ‘From Restricted to General Economy’ sees in Bataille’s perspective an undercutting of the overall Hegelian project consonant with his own ongoing deconstruction of Hegelian sublation. (...) I argue that not only does Hegel fail to adequately pursue his own best advice to ‘tarry with the negative,’ but Bataille and Derrida’s critique misconstrues the relation between sublation and dialectic in Hegel’s work. I explicate Adorno’s ‘negative dialectic’ by way of alternative both to Hegelian speculative dialectic and to its Bataillean–Derridean deconstruction. (shrink)